Although nucleosome positioning can be influenced by several factors, present nucleosome positioning data showed that nucleosomes have higher affinity for particular DNA sequences and intrinsic DNA sequence preference plays an important role in nucleosome positioning in vivo. 尽管有许多因素可以影响核小体的定位,但现有的核小体定位数据显示,核小体对特殊的DNA序列有高度的亲和力,DNA本身的序列在体内核小体定位中扮演很重要的角色。